Vol. 2 No. 4: June 2026

Cover of Volume 2, Issue 4

Published: 2026-06-17

Methods Note

Effectiveness of Differentiated Service Delivery ART Care Among Priority Populations in Sub-Saharan Africa: Evidence from a Systematic Review and Meta-analysis

Christine Muhumuza, Ruchius Philbert, Tamale Bridget
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Effectiveness of Point-of-Care Viral Load Testing Among Priority Populations in Sub-Saharan Africa: Evidence from a Systematic Review and Meta-analysis

Christine Muhumuza, Ruchius Philbert, Tamale Bridget
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Effectiveness of PrEP Initiation Among Priority Populations in Sub-Saharan Africa: Evidence from a Systematic Review and Meta-analysis

Christine Muhumuza, Ruchius Philbert, Tamale Bridget
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Effectiveness of HIV Self-Testing Among Priority Populations in Sub-Saharan Africa: Evidence from a Systematic Review and Meta-analysis

Christine Muhumuza, Ruchius Philbert, Bridget Tamale
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Unmasking heterogeneous treatment effects in clinical trials: a location-scale quantile meta-analysis framework (IPD-QMA)

Laiba Khan
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The Integrity Ratio and the Transparency Discount: a registry-based framework for correcting and pricing publication bias in evidence synthesis and HTA

Laiba Khan
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Short Meta-Analysis

Study overlap across 501 Cochrane reviews: quantifying non-independence for meta-research

Mahmood Ahmad
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Severe Asthma Biologics Ultra-Precision — Living Meta-Analysis (RapidMeta)

Hamood Saeed
JAK Inhibitors in Rheumatoid Arthritis — Living Meta-Analysis (RapidMeta)

Hamood Saeed

Research Article

Tool Paper

E156 Research Letter

COVID-19 Displacement

Okuyo Patience, Ruchius Philbert, Kindiki Agnes, Evelyn Nakuya
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SGLT2 Inhibitors and Heart Failure

Maheen Akbar
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The Cyclical Pattern of Boom and Bust in Research Has Left Africa Unprepared for Emergencies Such as Ebola

Grace Kemigisha, Idah Mokeira Mirera, Evelyn Nakuya, Mohammad Murtala Yusuf, Prossy Nabateregga
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Community led Research

Okuyo Patience, Ssanyu Josette M, Ruchius Philbert, Nabateregga Prossy, Evelyn Nakuya, Kindiki Agnes
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SGLT2 Inhibitors and Heart Failure Outcomes Across the Ejection Fraction Spectrum; a Systematic Review and Meta-Analysis

John Kokas Obwiin
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Pharma Continental Pipeline

Kumbukani Chikosa, Amumpaire Olivia, Bitness Lyabagaga, Njeodo Njongang Vigny, Natinael Berhane, Sebudde Nicholus, Kirabo Justine
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Sotagliflozin SGLT1/2i: A Transparent Living Meta-Analysis v13

Sara Ahmed Ahmed
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HIV Testing Services Uptake Among Adolescent Girls and Young Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Christine Muhumuza, Ruth Mpirirwe , Bridget Tamale , Michael Muhoozi
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Predatory Journal Risk and Structural Inequities in African Research Publishing: Implications for Uganda Predatory Journal Risk

Fadumo Said Hassan , Charles Bafaki, Kumbukani Chikosa, Kirabo Justine, Derrick Tumwesigye , Anna Nakirabira , Njeodo Njongang Vigny
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Africa’s Youth Researcher Pipeline and Structural Inequities in Clinical Trial Leadership: Implications for Uganda and the African Continent. Youth Researcher Pipeline

Michael Antwi Bosiako , Kirabo Justine, Derrick Tumwesigye , Anna Nakirabira, Mukisa Paul Brian , Natinael Berhane, Amumpaire Olivia
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SGLT2 Inhibitors in Heart Failure: Living Meta-Analysis Across the EF Spectrum

Hamood Saeed
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TruthCert: A Fail-Closed Certification Protocol for LLM Outputs in Evidence Synthesis

Ronnie Ssenfuma
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Vulnerable Population Protection: Structural Inequalities in Clinical Trial Investment

Nicholus Sebudde , Joanitah Namatovu , Edith Kanyesigye, Martha Alice Namiiro , Bitness Lyabagaga , Olivia Amumpaire , Joshua Tulengerayo
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Precision Medicine in Africa: A Systematic Review of Epilepsy Treatment Gap

Eleanor Sabuka
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Participant Compensation Ethics in African Trials: A Cross-Sectional Analysis of Trial Distribution and Ethical Implications

Amina Mohamud Fidow
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Sickle Cell Disease Neglect: A Mismatch Between Burden and Research in Africa

Peter Eyong Ebot, Randolf Fuanghene Wefuan, Jacob Muruhukye, Rita Ewah Mbah, Enu-Ma Obi-Asu , Spritney Nashua Ninpa, Ebere Olive Nwanja
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CT.gov Completion Cohort Debt

Mahmood Ahmad
Cochrane Data Extractor: Automated Dataset Harvesting from Cochrane Systematic Reviews

Mahmood Ahmad
Africa Forecast: Causal Health Forecasting for 54 African Countries 2026-2036

Nakhabi Anna
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Inequities in Clinical Trial Distribution for Neglected Tropical Diseases: A Cross-Sectional Analysis of Global Research Concentration

Ronald Bwambale, Mutebi, Nelson Nsubuga, Janepher Nabaasa, Aggrey Gavamukulya, Persis Tikabulamu, Phiona Obbo
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Dynamics of Zoonotic Disease at the One Health Interface: Evidence from a Systematic Review

Nakhabi Anna, Jacob Muruhukye, Eleanor Sabuka, Christopher Tibamwenda, Lauritta Chinazaekpere Ndufeiya, Gloria Margaret, Nanono, Nwanja Olive Ebere
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Assessment of PEPFAR Funding Reduction on the Quality of HIV Services at Sex Workers Outreach Program Clinics, Nairobi County, Kenya

Idah Mirera, Caroline Kawila, Jonathan Monda
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HIV Trial Saturation Index

Idah Mirera, Everlyne Nakuya, Nabaasa Janepher, Eyong Ebot, Fadumo Hassan
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Informed Consent Language and Structural Inequity in African Clinical Trial Governance: A Cross-Sectional Audit

Musoke Muhammad, Ivan Mutyaba, Huzaifah Mutyaba, Tom Okade, Martina Uisso, Shamim Nabidda, Ssenfuma Ronnie
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Artificial Intelligence in Clinical Trials: A Cross-Sectional Analysis of Structural Inequities in African and United States Research Investment

Frank Matovu, Lauryn Nsenga, Simachew Getaneh Endalamew, Mary Nafuna
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Precision Medicine in Africa: A Systematic Review of Genomic Resilience and Structural Gaps

Muruhukye Jacob, Eleanor Sabuka, Anna Nakhabi, Mukisa Paul Brian, Nanono Gloria Margaret, Nabateregga Prossy, Eyong Peter Ebot
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Geographic Inequity in African Clinical Trials: A Systematic Review Evidence of a Port-City Advantage

John Kokas Obwiin
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Sample Size Adequacy Audit

Joy Osifo
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The Antimicrobial-Resistance “Trial Deficit” in Africa, Re-examined: Why the Headline Statistic Fails and What the Real Gap Is Antimicrobial Resistance Crisis

Gloria Margaret Nanono, Christopher Tibamwenda, Jacob Muruhukye, Grace Kemigisa, Peter Ebot Eyong, Fiona Obbo, Prossy Nabateregga
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WHO Alignment and Disease Burden Gaps

Michael Bosiako Antwi, Njeodo Njongang Vigny , Shamim Nabidda , Tukamushaba Bruce , Christine Muhumuza , Fadumo Said Hassan , Ssenfuma Ronnie
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Community advisory structure in African clinical trials: A registry-based analysis

Peter Eyong Ebot, Jacob Muruhukye, James Mukiibi, Spritney Nashua Ninpa , Christopher Tibamwenda, Meldwinel Ayuk , Prossy Nabateregga
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Reappraising Evidence for Intravascular Imaging–Guided PCI

Majed Sheikh
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The PLATO trial - was it too good to be true?

Daniel Coles
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AS-Logic: Computing the Tipping Point in Asymptomatic Severe Aortic Stenosis

Niraj S Kumar, Ruhani Singh
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Treatment Decisions Based on EF ≥50% Require More Robust Statistical Validation

Syed Muhammad Ali
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Global CVD Trends and Regional Risk‐Profile Clustering Using GBD 2022 Data Global CVD Trends

Laiba Khan, Maham Khan, Muhammad Hamza Khan, Joanne Lac
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Research Sovereignty in African Clinical Trials: A Network Analysis of Global North and Global South Partnerships.

Caroline Nakalema, Peter Mulindwa
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AU Health Strategy Alignment and Inequality in African Clinical Trials: A Cross-Sectional Analysis of ClinicalTrials.gov Data

Justine Kirabo, Anna Nankabira, Shamim Nabidda, Aminah Mohamud Fidow, Christine Muhumuza, Ronnie Ssenfuma, Derrick Tumwesigye
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CardioOracle: Predicting Cardiovascular Trial Outcomes Using Bayesian Historical Borrowing and Design Feature Analysis

Syed Muhammad Ali
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The Bio-Digital Divide: Digital trial adoption and the Bio-digital gap in Africa

Peter Ebot Eyong, Jacob Muruhukye, Rita Ewah Mbah, Endurance Lum Ambe, Vahid Esangaya Ntoung-Mbi , Spritney Nashua Ninpa , Gloria Margaret Nanono
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The Network Entropy and Structural Disorder in African Clinical Research: A Meta-Analysis Review

Mahad Muweesi, Malinga Odong, Joyce Nayiga, Solomon Wani
Knowledge Extraction and Local Utilization of Clinical Trial Evidence in Uganda: A Systematic Review and Meta-Analysis

Adrine Nyamwiza
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Global RCT Equity: Africa vs. Europe

Geofrey Emesu, Lauritta Chinezaekpere Ndufeiya, Everlyn Nakuya, Ronald Bwambale, Peter Eyong Ebot, Gloria Margaret Nanono
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Decolonising Research

Derrick Tumwesigye; Ruchius Philbert; Christine Muhumuza
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Digital Health Trial Explosion and Structural Inequities in African Clinical Research: A Meta-Analysis Review

John Francis Kimuli, Ishmael Gumbo, Simachew Getaneh Endalamew, Frank Matovu
RoBVisShiny: An Interactive R Shiny Application for Visualizing Risk-of-Bias Assessments

Laiba Khan, Maham Khan, Muhammad Hamza Khan, Joanne Lac
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Altruism Efficiency & Health Expenditure

Paul Brian Mukisa
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Applying Placebo Ethics Audit findings to Uganda: Health System Challenges and Ethical Consideration in Clinical Trials

Fadumo Said Hassan
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The Breast Cancer Clinical Trial Disparities in Africa: Limited Evidence for a High-Burden Population Limited Evidence for a High-Burden Population

Janepher Nabaasa, Nabaasa Janepher, Eyong Peter
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Network Centrality and Research Sovereignty in African Clinical Trials: Evidence from a Global Registry Analysis

Samuel Munyole, Alice Martha Namiiro, Bitness Edward Lyabagaga, Edith Kanyesigye, Joanitah Namatovu, Olivia Amumpaire, Adrine Nyamwiza
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Structural Inequity in Research Investment and Africa’s Readiness for Platform Trials: A Meta-Analysis

Zelda Sandra Mwebe, Felix Kofi Awuriki, Kimuli John Francis
The Cervical Cancer HPV Gap

Muhammad Murtala Yusuf, Zainab Abdulazeez , Fatima Abdullahi Hari, Rukayya Ado Bello, Shamsudeen Shuaibu, Grace Kemigisha, Eyong Peter Ebot
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Research Archetypes and Cluster Mapping Narratives: A Semantic Comparison of Africa and Europe Understanding innovation and evaluation framing in global Research Archetypes and Cluster Mapping

Agnes Kindiki, Tibamwenda Christopher, Muruhukye Jacob, Kindiki Agnes, Nabateregga Prossy, Eyong Peter Ebot
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Beyond the Gap: 80% Use, 0.0% Trials — The Traditional Medicine Research Void Across Africa Traditional Medicine Integration

Grace Kemigisha, Anna Nakhabi, Evelyn Nakuya, Peter Eyong Ebot, Mohammad Murtala Yusuf; Gloria Margaret Nanono
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E468 Short Report

RR/OR NMA: An Interactive R Shiny App for Conducting Frequentist Network Meta-Analysis of Ratio Outcomes

Laiba Khan, Maham Khan, Muhammad Hamza Khan, Joanne Lac
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Case Report

Disseminated Nocardiosis – A rare case of Nocardia kroppenstedtii in a Ghanaian adult – A case report

Faiqa Bashir, Hamza Basheer
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