Synthesis

Announcements

Welcome to Synthesis

2026-06-06

Synthesis has been publishing open-access, peer-reviewed research since November 2025. Read more about Welcome to Synthesis

Current Issue

Vol. 2 No. 7: September 2026

Published: 2026-09-01

Research Article

Sponsor-Level Accountability on ClinicalTrials.gov: Modality-Stratified Backlog, Ghost Protocols, Overdue Debt, and Narrative-Field Gaps in 249,507 Older Closed Studies

Andrew Woo
- PDF
- JATS XML
The Country Anatomy of CT.gov Transparency Gaps: A Fourteen-Lens Audit of 249,507 Older Closed Interventional Studies

Andrew Woo
- PDF
- JATS XML
The Disease-Family Anatomy of CT.gov Transparency: Eleven Condition-Stratified Dimensions across 249,507 Older Closed Interventional Studies

Andrew Woo
- PDF
- JATS XML
The Anatomy of Hiddenness: A Multi-Axis Audit of Structural Non-Disclosure in ClinicalTrials.gov

Andrew Woo
- PDF
- JATS XML

E156 Research Letter

Pharma Continental Pipeline

Kumbukani Chikosa, Amumpaire Olivia, Bitness Lyabagaga, Njeodo Njongang Vigny, Natinael Berhane, Sebudde Nicholus, Kirabo Justine
- PDF
- JATS XML
Benford Screening of 1.2 Million Meta-Analytic Values Finds No Corpus-Level Digit Anomaly

Zaki Khan
- PDF
- JATS XML
CT.gov Structural Missingness: Field-level information loss across the full ClinicalTrials.gov registry

Zaki Khan
- PDF
- JATS XML
TrialDiversityAtlas — Quantifying Demographic Representation Gaps in Global Clinical Trials

Zaki Khan
- PDF
- JATS XML
OutcomeSwitchDetector: Automated Detection of Primary Outcome Switching in ClinicalTrials.gov Protocols

Zaki Khan
- PDF
- JATS XML
Two reporting requirements, divergent compliance: results-posting rises while PCR-correction stalls in 2,039 registered malaria trials

Zaki Khan
- PDF
- JATS XML
NCT-bridge methodology is structurally blind to PACTR-registered African trial publications

Zaki Khan
- PDF
- JATS XML
NICE Cardiology Guidance Under the Microscope: A Data-Driven Statistical Critique

Zaki Khan
- PDF
- JATS XML
Meta-analytic entropy: information-theoretic heterogeneity beyond I-squared

Mahmood Ahmad
- PDF
- JATS XML
HIV Testing Services Uptake Among Adolescent Girls and Young Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Christine Muhumuza, Ruth Mpirirwe , Bridget Tamale , Michael Muhoozi
- PDF
- JATS XML
COVID-19 Displacement

Okuyo Patience, Ruchius Philbert, Kindiki Agnes, Evelyn Nakuya
- PDF
- JATS XML
Vulnerable Population Protection: Structural Inequalities in Clinical Trial Investment

Nicholus Sebudde , Joanitah Namatovu , Edith Kanyesigye, Martha Alice Namiiro , Bitness Lyabagaga , Olivia Amumpaire , Joshua Tulengerayo
- PDF
- JATS XML
Precision Medicine in Africa: A Systematic Review of Epilepsy Treatment Gap

Eleanor Sabuka
- PDF
- JATS XML
Participant Compensation Ethics in African Trials: A Cross-Sectional Analysis of Trial Distribution and Ethical Implications

Amina Mohamud Fidow
- PDF
- JATS XML
Sickle Cell Disease Neglect: A Mismatch Between Burden and Research in Africa

Peter Eyong Ebot, Randolf Fuanghene Wefuan, Jacob Muruhukye, Rita Ewah Mbah, Enu-Ma Obi-Asu , Spritney Nashua Ninpa, Ebere Olive Nwanja
- PDF
- JATS XML
AU Health Strategy Alignment and Inequality in African Clinical Trials: A Cross-Sectional Analysis of ClinicalTrials.gov Data

Justine Kirabo, Anna Nankabira, Shamim Nabidda, Aminah Mohamud Fidow, Christine Muhumuza, Ronnie Ssenfuma, Derrick Tumwesigye
- PDF
- JATS XML
The Bio-Digital Divide: Digital trial adoption and the Bio-digital gap in Africa

Peter Ebot Eyong, Jacob Muruhukye, Rita Ewah Mbah, Endurance Lum Ambe, Vahid Esangaya Ntoung-Mbi , Spritney Nashua Ninpa , Gloria Margaret Nanono
- PDF
- JATS XML
Africa’s Youth Researcher Pipeline and Structural Inequities in Clinical Trial Leadership: Implications for Uganda and the African Continent. Youth Researcher Pipeline

Michael Antwi Bosiako , Kirabo Justine, Derrick Tumwesigye , Anna Nakirabira, Mukisa Paul Brian , Natinael Berhane, Amumpaire Olivia
- PDF
- JATS XML
Predatory Journal Risk and Structural Inequities in African Research Publishing: Implications for Uganda Predatory Journal Risk

Fadumo Said Hassan , Charles Bafaki, Kumbukani Chikosa, Kirabo Justine, Derrick Tumwesigye , Anna Nakirabira , Njeodo Njongang Vigny
- PDF
- JATS XML
Community led Research

Okuyo Patience, Ssanyu Josette M, Ruchius Philbert, Nabateregga Prossy, Evelyn Nakuya, Kindiki Agnes
- PDF
- JATS XML
The Cyclical Pattern of Boom and Bust in Research Has Left Africa Unprepared for Emergencies Such as Ebola

Grace Kemigisha, Idah Mokeira Mirera, Evelyn Nakuya, Mohammad Murtala Yusuf, Prossy Nabateregga
- PDF
- JATS XML

View All Issues

Diamond open-access journal for concise, reproducible medical evidence synthesis

Synthesis publishes concise, reproducible evidence syntheses and structured methods notes, each linked to its data. No author or reader fees · CC BY 4.0 · authors retain copyright.

Submit Current issue Author guidelines

Peer review Open access & fees Indexing status Editorial board Contact

Browse the Archive

June 2026

May 2026

April 2026

March 2026

December 2025

November 2025