Amoxicillin for Adults randomized in trials registered on ClinicalTrials.gov for Otitis Media: a short systematic review and meta-analysis

Abstract

Adults randomised in trials registered on ClinicalTrials.gov for Otitis Media face risks related to Trial-declared primary outcome. Amoxicillin has been evaluated versus Active comparator or placebo in randomised controlled trials. This short systematic review synthesises the randomised evidence.

To assess whether Amoxicillin reduces Trial-declared primary outcome compared with Active comparator or placebo in Adults randomised in trials registered on ClinicalTrials.gov for Otitis Media.

In Adults randomised in trials registered on ClinicalTrials.gov for Otitis Media, Amoxicillin appears to affect Trial-declared primary outcome compared with Active comparator or placebo (RR 1.16, 95% CI 0.96 to 1.41). These results should be interpreted cautiously given the certainty of the evidence.