786-MIII Medicine is a diamond open access publishing platform dedicated to advancing evidence synthesis methodology and global health equity through innovative scholarly communication.

Our Platform

This site hosts a family of 12 specialized journals, each focused on different aspects of evidence synthesis, meta-analysis methodology, and evidence-based medicine. United by our commitment to methodological rigor and accessibility, our journals serve researchers, clinicians, policymakers, and methodologists worldwide.

 

Journals

  • Synthēsis

    Synthēsis is a methods-driven venue for concise meta-analyses across all medical specialties. We aim to raise the signal-to-noise ratio in evidence synthesis by combining tight word limits with uncompromising methodological transparency. Each article addresses one clearly defined clinical, diagnostic, prognostic, public-health, or health-services question; uses appropriate models (random-effects by default); and reports heterogeneity with I², τ², and 95% prediction intervals to support real-world interpretation.

    Reproducibility is mandatory. Submissions must include:

    • A pre-registered protocol (e.g., PROSPERO or OSF).

    • Complete search strategies and a PRISMA 2020 flow diagram.

    • Risk-of-bias assessment (e.g., RoB 2 for trials; ROBINS-I for observational studies).

    • Open data and analysis code with persistent DOIs (e.g., Zenodo/OSF), plus session info to ensure reruns.

    We encourage succinct graphics (forest plot; optional funnel plot when k ≥ 10) and a Summary of Findings snapshot with GRADE certainty ratings. Scope spans therapeutics, diagnostics, prognostics, screening, prevention, health policy/services, and population health, including specialty domains such as cardiology, oncology, neurology, infectious diseases, paediatrics, mental health, surgery, and primary care.

    Article types

    • Short Meta-Analysis (≤400 words): Single-question quantitative synthesis with full transparency (appendices host methods, data, and code).

    • Methods Note (≤400 words): Concise advances or best-practice guides for meta-analysis methods (e.g., time-to-event synthesis, small-study effects, prediction intervals).

    • Brief Update (≤400 words): Rapid updates to prior syntheses when new evidence materially changes conclusions.

    Reporting expectations
    Protocol ID/DOI; PRISMA checklist; RoB and GRADE; open data/code (with DOIs); explicit model choice (e.g., REML with Hartung–Knapp when applicable); forest plot; and interpretation framed for clinicians, policymakers, or other decision-makers.

  • Insight

    Journal Description for Insight:

    Insight is a diamond open access journal publishing ultra-brief meta-analyses, methodological innovations, and evidence updates in a revolutionary 400-word format.

    In Insight, the abstract is the paper. Every submission - whether a complete meta-analysis, a methods innovation, or an evidence update - must convey all essential information within 400 words. This format eliminates barriers between evidence and action, enabling clinicians and policymakers to access, assess, and apply research findings in minutes rather than hours.

    What we publish:

    • Meta-analyses (400 words): Complete systematic reviews and meta-analyses presenting search strategy, inclusion criteria, pooled effect estimates, heterogeneity assessment, and clinical implications.
    • Methods papers (400 words): Novel meta-analytic techniques, statistical innovations, bias assessment tools, or methodological critiques distilled to their essential elements.
    • Meta-analysis updates (400 words): Rapid updates to published meta-analyses incorporating new trial data or methodological refinements.

    All submissions may include supplementary files (forest plots, tables, or detailed statistical outputs) but must be complete and independently interpretable within the 400-word limit.

    Our mission:

    Evidence synthesis generates actionable knowledge, yet traditional formats create delays between discovery and implementation. Insight accelerates evidence dissemination without compromising rigor. Every paper undergoes rapid peer review focusing on methodological soundness, clarity, and clinical relevance.

    Insight complements our sister journal Synthesis, which publishes comprehensive meta-analyses and in-depth methodological work. Together, they serve the full spectrum of evidence synthesis needs.

    Indexing & Standards:

    All articles receive DOIs, are indexed in Google Scholar, and follow PRISMA reporting standards adapted for ultra-brief formats.

  • Gnosis

    Gnosis is a diamond open access journal publishing evidence synthesis for global health. We publish complete meta-analyses, methodological innovations, and evidence updates in exactly 400 words - where the abstract is the paper - with specific focus on evidence relevant to low- and middle-income countries (LMICs).

    Mission

    Most systematic reviews and meta-analyses are conducted in high-income settings, analyzing trials from wealthy populations, with little consideration of transportability to resource-limited contexts. Insight addresses this evidence gap by prioritizing:

    • Meta-analyses of interventions feasible in resource-limited settings
    • Evidence from LMIC populations and healthcare systems
    • Transportability analysis: how findings from high-income trials apply to developing country contexts
    • Cost-effectiveness relevant to constrained health budgets
    • Implementation considerations for low-resource settings

    Our 400-word format serves clinicians and policymakers in developing countries who need rapid, accessible evidence without bandwidth limitations, subscription barriers, or time to read 8,000-word papers.

    Focus and Scope

    Priority topics:

    • Infectious diseases (tuberculosis, malaria, HIV, neglected tropical diseases)
    • Maternal and child health interventions
    • Non-communicable disease prevention in resource-limited settings
    • Essential medicines and generic formulations
    • Task-shifting and community health worker interventions
    • Low-cost diagnostic strategies
    • Implementation science in LMICs

    We publish three article types:

    • Meta-analyses (400 words): Complete evidence synthesis with explicit consideration of applicability to LMIC settings, including cost, infrastructure requirements, and local evidence when available
    • Methods papers (400 words): Innovations in transportability assessment, evidence synthesis for resource-limited settings, or methods addressing LMIC-specific challenges
    • Evidence updates (400 words): Rapid incorporation of new LMIC trial data into existing meta-analyses

    Why This Matters

    The global evidence gap:

    • 90% of health research funding goes to diseases affecting 10% of the global population
    • Most RCTs exclude populations typical of developing countries (co-morbidities, malnutrition, co-infections)
    • Systematic reviews rarely assess whether findings transport from trial populations to real-world LMIC contexts
    • Paywalls prevent clinicians in developing countries from accessing evidence

    Insight's approach:

    • Diamond open access - no fees for authors or readers
    • Minimal bandwidth - 400 words loads instantly on slow connections
    • Practical focus - every paper must address feasibility in resource-limited settings
    • Rapid dissemination - 48-72 hour peer review enables timely evidence for outbreaks, policy decisions, and guideline development

    Open Access Policy

    Complete diamond open access:

    • No article processing charges (APCs)
    • No subscription fees
    • Immediate publication under CC-BY 4.0 license
    • Authors retain copyright
    • Pre-print posting encouraged

    This model ensures researchers in low-income countries can both publish and access evidence without financial barriers.

    Reporting Standards

    All meta-analyses must include:

    • Explicit discussion of applicability to LMIC settings
    • Assessment of intervention feasibility (cost, infrastructure, expertise required)
    • LMIC-specific subgroup analyses when data permits
    • Adapted PRISMA 2020 standards

    We encourage reporting:

    • Cost per patient in purchasing power parity (PPP) terms
    • Training requirements for implementation
    • Essential equipment or infrastructure needs
    • Transportability metrics when applicable

    Editorial Board

    Our editorial board spans six continents with majority representation from LMIC institutions. Peer reviewers are selected for expertise in both methodology and local context, ensuring evidence is both rigorous and relevant.

    Sponsorship and Independence

    Insight receives no pharmaceutical or industry funding. We are supported by [institutional/foundation support] committed to global health equity. All funding sources are disclosed. Authors must declare sponsor involvement in study design and analysis.

    Privacy and Ethics

    Names and emails are used only for journal purposes. Peer review is confidential. We follow COPE guidelines and require ethical approval disclosure for all included studies.

    Archiving

    • LOCKSS and CLOCKSS preservation
    • PKP Preservation Network
    • Institutional repository deposits encouraged
    • Persistent DOIs via CrossRef (applied for)