Methodological Update:
1. HKSJ Adjustment: Standard Errors are adjusted using Hartung-Knapp-Sidik-Jonkman method for small study counts.
2. Dynamic Prediction: Intervals use t-distribution critical values based on degrees of freedom ($k-2$).
3. Interaction: Subgroup p-values calculated when mixing modalities.
Primary Composite Endpoint
Random Effects (DerSimonian-Laird + HKSJ)
--
--
Pooled HR (HKSJ)
--
95% PI
Prediction Int
--
--
Heterogeneity
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Subgroup Test
Interaction P
--
--
Model P-Value
Translation
Clinical Impact (Per 100)NNT Analysis
NNT: -- [95% CI: -- to --]
Events Prevented
Possible Harm
Subgroup Details
TAVR Estimate
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SAVR Estimate
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Heterogeneity (I²)
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Evidence Certainty
* Assumes 30% baseline risk over 4 years based on control arms of comprised trials.